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Genetic influence on language delay in two-year-old children

Abstract

Previous work suggests that most clinically significant language difficulties in children do not result from acquired brain lesions or adverse environmental experiences but from genetic factors that presumably influence early brain development. We conducted the first twin study of language delay to evaluate whether genetic and environmental factors at the lower extreme of delayed language are different from those operating in the normal range. Vocabulary at age two was assessed for more than 3000 pairs of twins. Group differences heritability for the lowest 5% of subjects was estimated as 73% in model-fitting analyses, significantly greater than the individual differences heritability for the entire sample (25%). This supports the view of early language delay as a distinct disorder. Shared environment was only a quarter as important for the language-delayed sample (18%) as for the entire sample (69%).

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References

  1. Bates, E., Dale, P.S. & Thal, D. in Handbook of Child Language (eds Fletcher, P. & MacWhinney, B.) 96–151 (Basil, Blackwell, Oxford, 1995).

    Google Scholar 

  2. Elman, J.L. et al. Rethinking Innateness: A Connectionist Perspective on Development (MIT Press, Cambridge, Massachusetts, 1996).

    Google Scholar 

  3. Pinker, S. The Language Instinct (William Morrow, New York, 1994).

    Book  Google Scholar 

  4. Hampson, J. & Nelson, K. The relation of maternal language to variation in rate and style of language acquisition. J. Child Lang. 20, 313–342 ( 1993).

    Article  CAS  Google Scholar 

  5. Huttenlocher, J., Haight, W., Bryk, A., Seltzer, M. & Lyons, T. Early vocabulary growth: Relation to language input and gender. Dev. Psychol. 27, 236– 248 (1991).

    Article  Google Scholar 

  6. Hart, B. & Risley, T.R. Meaningful Differences in the Everyday Experience of Young American Children (P. H. Brookes, Baltimore, 1995).

    Google Scholar 

  7. Lytton, H. Parent-Child Interaction: The Socialization Process Observed in Twin and Singleton Families (Plenum, New York, 1980).

    Book  Google Scholar 

  8. Bishop, D.V.M. Uncommon Understanding: Development and Disorders of Language Comprehension in Children (Psychology Press, Hove, UK, 1997).

    Google Scholar 

  9. Bishop, D.V.M., North, T. & Donlan, C. Genetic basis of specific language impairment: Evidence from a twin study. Dev. Med. Child. Neurol. 37, 56–71 (1995).

    Article  CAS  Google Scholar 

  10. Lewis, B.A. & Thompson, L.A. A study of developmental speech and language disorders in twins. J. Speech Hear. Res. 35, 1086–1094 (1992).

    Article  CAS  Google Scholar 

  11. Tomblin, J.B. & Buckwalter, P.R. Heritability of poor language achievement among twins. J. Speech Lang. Hear. Res. 41, 188–199 (1998).

    Article  CAS  Google Scholar 

  12. Felsenfeld, S. & Plomin, R. Epidemiological and offspring analyses of developmental speech disorders using data from the Colorado Adoption Project . J. Speech Lang. Hear. Res. 40, 778– 791 (1997).

    Article  CAS  Google Scholar 

  13. Leonard, L. in Advances in Applied Psycholinguistics, Volume 1: Disorders of First-Language Development (ed. Rosenberg, S.) 1–39 (Cambridge University Press, New York, 1987).

    Book  Google Scholar 

  14. Fenson, L. et al. Variability in early communicative development. Monogr. Soc. Res. Child Dev. 59, 1–173 ( 1994).

    Article  CAS  Google Scholar 

  15. Hart, H., Bax, M. & Jenkins, S. Use of the child health clinic. Arch. Dis. Child. 56 , 440–445 (1981).

    Article  CAS  Google Scholar 

  16. Rescorla, L., Roberts, J. & Dahlsgaard, K. Late talkers at 2: Outcome at age 3. J. Speech Lang. Hear. Res. 40, 556–566 (1997).

    Article  CAS  Google Scholar 

  17. Thal, D.J. & Katich, J. in Assessment of Communication and Language (eds Cole, K. N., Dale, P. S. & Thal, D. J.) 1– 28 (Paul H. Brookes, Baltimore, 1997).

    Google Scholar 

  18. Beitchman, J.H. Cohen, N.J. Konstantareas, M.M. & Tannock, R. Language, Learning, and Behavior Disorders: Developmental, Biological, and Clinical Perspectives (Cambridge University Press, New York, 1996).

    Google Scholar 

  19. DeFries, J.C. & Fulker, D.W. Multiple regression analysis of twin data. Behav. Genetics 15, 467– 473 (1985).

    Article  CAS  Google Scholar 

  20. DeFries, J.C. & Fulker, D.W. Multiple regression analysis of twin data: Etiology of deviant scores versus individual differences. Acta Genet. Med. Gemellol. 37, 205– 216 (1988).

    Article  CAS  Google Scholar 

  21. Goldsmith, H.H. A zygosity questionnaire for young twins: A research note. Behav. Genet. 21, 257–269 ( 1991).

    Article  CAS  Google Scholar 

  22. Freeman, B., Ball, D., Powell, J., Craig, I. & Plomin, R. DNA by mail: The usefulness of cheek scrapings. Behav. Genet. 27, 251–257 (1997).

    Article  CAS  Google Scholar 

  23. Rutter, M. & Redshaw, J. Annotation: Growing up as a twin: Twin-singleton differences in psychological development. J. Child Psychol. Psychiatry 32, 885–895 (1991).

    Article  CAS  Google Scholar 

  24. McGue, M. & Bouchard, T.J. Jr Adjustment of twin data for the effects of age and sex. Behav. Genet. 14, 325–343 (1984).

    Article  CAS  Google Scholar 

  25. Martin, N.G., Eaves, L.J., Kearsey, M.J. & Davies, P. The power of the classical twin study. Heredity 40, 97– 116 (1978).

    Article  CAS  Google Scholar 

  26. Reznick, J.S., Corley, R. & Robinson, J. A longitudinal twin study of intelligence in the second year. Monogr. Soc. Res. Child Dev. 249, 1– 160 (1997).

    Google Scholar 

  27. DeFries, J.C. & Gillis, J.J. in Nature, Nurture and Psychology (eds Plomin, R. & McClearn, G. E.) 121–145 (American Psychological Association, Washington, DC, 1993).

    Book  Google Scholar 

  28. Bishop, D.V.M. in Child and Adolescent Psychiatry (eds Rutter, M., Hersov, L. & Taylor, E.) 546–568 (Blackwell Scientific, Oxford, 1994).

    Google Scholar 

  29. Fisher, S.E., Vargha-Khadem, F., Watkins, K.E., Monaco, A.P. & Pembrey, M.E. Localisation of a gene implicated in a severe speech and language disorder. Nat. Genet. 18, 168 –170 (1998).

    Article  CAS  Google Scholar 

  30. Plomin, R., DeFries, J.C., McClearn, G.E. & Rutter, M. Behavioral Genetics (W.H.Freeman, New York, 1997).

    Google Scholar 

  31. Martin, N., Boomsma, D. & Machin, G. A twin-pronged attack on complex trait. Nat. Genet. 17, 387–392 (1997).

    Article  CAS  Google Scholar 

  32. Phillips, D.I.W. Twin studies in medical research: Can they tell us whether diseases are genetically determined? Lancet 341, 1008–1009 (1993).

    Article  CAS  Google Scholar 

  33. Christensen, K., Vaupel, J.W., Holm, N.V. & Yashin, A.I. Mortality among twins after age 6: fetal origins hypothesis versus twin method. B. M. J. 310, 432–436 ( 1995).

    Article  CAS  Google Scholar 

  34. Falconer, D.S. The inheritance of liability to certain diseases estimated from the incidence among relatives . Ann. Hum. Genet. 29, 51– 76 (1965).

    Article  Google Scholar 

  35. Smith, C. Concordance in twins: Methods and interpretation. Am. J. Hum. Genet. 26, 454–466 (1974).

    CAS  PubMed  PubMed Central  Google Scholar 

  36. Saudino, K.J., Plomin, R., Pedersen, N.L. & McClearn, G.E. The etiology of high and low cognitive ability during the second half of the life span . Intelligence 19, 353– 371 (1994).

    Article  Google Scholar 

  37. Neale, M.C. & Cardon, L.R. Methodology for Genetic Studies of Twins and Families (Kluwer Academic Publications, Dordrecht, 1992).

Download references

Acknowledgements

We thank the parents of the twins in the Twins Early Development Study (TEDS) for making the study possible. TEDS is supported by a programme grant from the UK Medical Research Council.

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Correspondence to Robert Plomin.

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Dale, P., Simonoff, E., Bishop, D. et al. Genetic influence on language delay in two-year-old children. Nat Neurosci 1, 324–328 (1998). https://doi.org/10.1038/1142

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