The transcription factor hypoxia-inducible factor 1 (HIF-1) triggers multiple cellular responses to cope with hypoxia. A study in this issue suggests that elevated HIF-1 also causes axon guidance defects under hypoxic conditions.
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Kim Caesar
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Pan, CL., Garriga, G. Fresh air is good for nerves: hypoxia disturbs axon guidance. Nat Neurosci 11, 859–861 (2008). https://doi.org/10.1038/nn0808-859
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DOI: https://doi.org/10.1038/nn0808-859
