Unraveling the ribbon synapse

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A new study identifies pikachurin, a previously-unknown dystroglycan-binding protein that is critical for the apposition of photoreceptor and bipolar cell dendrites at the ribbon synapse. This work could explain some of the visual defects seen in several muscular dystrophies.

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Figure 1: Pikachurin is necessary for the apposition of photoreceptor and bipolar cell termini.

Kim Caesar

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Satz, J., Campbell, K. Unraveling the ribbon synapse. Nat Neurosci 11, 857–859 (2008) doi:10.1038/nn0808-857

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