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Nicotinic receptor structure emerging slowly

A high-resolution crystal structure of the ligand-binding domain of the human nicotinic acetylcholine receptor α subunit, with three point mutations to improve its crystallization, provides both reassurance and exciting new insights.

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Figure 1: The α subunit of the nAChR ligand binding domain has been resolved at high resolution.
Figure 2: Features of the new nAChR α subunit structure.


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Sixma, T. Nicotinic receptor structure emerging slowly. Nat Neurosci 10, 937–938 (2007).

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