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Controlling neuron number: does Numb do the math?

Nature Neuroscience volume 7, pages 793–794 (2004)Cite this article

Numb is an important developmental protein that functions in fate determination, differentiation and cell maturation, but its role in mammalian neural progenitors has been controversial. A new paper uses a clever approach to attempt to reconcile the opposing views.

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Figure 1: Opposing views of Numb and Numblike function in maintaining progenitor status or promoting neural fate during asymmetric cell division in mammals.

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Authors and Affiliations

  1. Departments of Neurology and Physiology and Cellular Biophysics, Columbia University, New York, New York, USA

    David R Castañeda-Castellanos

  2. Departments of Neurology and Pathology and the center for Neurobiology and Behavior, Columbia University, New York, New York, USA

    Arnold R Kriegstein

Authors
  1. David R Castañeda-Castellanos
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  2. Arnold R Kriegstein
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Castañeda-Castellanos, D., Kriegstein, A. Controlling neuron number: does Numb do the math?. Nat Neurosci 7, 793–794 (2004). https://doi.org/10.1038/nn0804-793

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