We are pleased to announce that the 2000 impact factor for Nature Neuroscience is 12.636. This represents a 42% increase over its 1999 impact factor (8.863), and places us fifth out of 205 neuroscience journals, according to the Institute for Scientific Information. Although we encourage readers to interpret these numbers with caution—and have argued previously1 that impact factors are often misunderstood and misused—we nevertheless like to think that this healthy increase is a reflection of our growing influence and standing within the neuroscience community.