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Selective localization of cardiac SCN5A sodium channels in limbic regions of rat brain

Nature Neuroscience volume 2, pages 593–595 (1999)Cite this article

Abstract

Voltage-dependent sodium channels have a critical role in membrane electrogenesis and repetitive firing in excitable cells. Members of this gene superfamily exhibit diffuse, tissue-specific expression in nervous, muscle and cardiac tissues1. Tetrodotoxin (TTX) sensitivity and resistance to zinc blockade were thought to distinguish brain from heart sodium channels, but neuronal Na+ currents with heart-like properties have been found in brain2.

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Figure 1: Autoradiograms of labeled antisense probe for the I–II linker region (Pr1) of SCN5A reveal selective expression in limbic circuitry of the rat brain.
Figure 2: RT-PCR analysis of regional SCN5A expression in rat brain.

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Acknowledgements

This research was supported by the Curtis Hankamer Foundation and American Heart Association G98-193 (H.A.H.), National Institutes of Health NS 29709 and the Blue Bird Foundation for Pediatric Neurology (J.L.N.).

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Authors and Affiliations

  1. Department of Molecular Physiology and Biophysics One Baylor Plaza, Baylor College of Medicine, Houston, 77030, Texas, USA

    Hali A. Hartmann

  2. Department of Neurology, One Baylor Plaza, Baylor College of Medicine, Houston, 77030, Texas, USA

    Luis V. Colom, Margaret L. Sutherland & Jeffrey L. Noebels

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  1. Hali A. Hartmann
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  2. Luis V. Colom
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  3. Margaret L. Sutherland
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  4. Jeffrey L. Noebels
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Correspondence to Jeffrey L. Noebels.

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Hartmann, H., Colom, L., Sutherland, M. et al. Selective localization of cardiac SCN5A sodium channels in limbic regions of rat brain. Nat Neurosci 2, 593–595 (1999). https://doi.org/10.1038/10147

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