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Caspases land on APP: One small step for apoptosis, one giant leap for amyloidosis?

Nature Neuroscience volume 2, pages 585–586 (1999)Cite this article

Abstract

Gervais et al. suggest that caspase cleavage of amyloid precursor protein (APP) may initiate a feedback loop that produces β-amyloid deposits in Alzheimer's disease.

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Figure 1: A model for the relationship between caspase activation, caspase cleavage of APP and the generation of Aβ, including the role of presenilin FAD mutations.

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Authors and Affiliations

  1. Department of Neurology, Harvard Medical School, Massachusetts General Hospital, 149 13 th Street, Charleston, 02129, Massachusetts, USA

    Rudolph E. Tanzi

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  1. Rudolph E. Tanzi
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Tanzi, R. Caspases land on APP: One small step for apoptosis, one giant leap for amyloidosis?. Nat Neurosci 2, 585–586 (1999). https://doi.org/10.1038/10133

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