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Reactive oxygen species are NOXious for neurons

Nature Neuroscience volume 12, pages 819–820 (2009)Cite this article

Mitochondria are considered to be the main source of reactive oxygen species during glutamate excitotoxicity. Data now support a prominent role in this process for NADPH oxidase, the enzyme that neutrophils use to kill bacteria.

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Figure 1: The role of NOX2 in ROS production in excitotoxicity.

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Authors and Affiliations

  1. Nicolas Demaurex and Luca Scorrano are in the Department of Cell Physiology and Metabolism, University of Geneva Medical School, Genève, Switzerland.,

    Nicolas Demaurex & Luca Scorrano

  2. Luca Scorrano is at the Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, Padova, Italy.,

    Luca Scorrano

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  1. Nicolas Demaurex
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  2. Luca Scorrano
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Correspondence to Nicolas Demaurex or Luca Scorrano.

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Demaurex, N., Scorrano, L. Reactive oxygen species are NOXious for neurons. Nat Neurosci 12, 819–820 (2009). https://doi.org/10.1038/nn0709-819

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