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Spikes versus BOLD: what does neuroimaging tell us about neuronal activity?

By demonstrating that fMRI responses in human MT+ increase linearly with motion coherence and comparing these responses with slopes of single-neuron firing rates in monkey MT, a new paper provides the best evidence so far that fMRI responses are proportional to firing rates.

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Figure 1: Average firing rate in monkey MT increases linearly with motion coherence.
Figure 2: fMRI responses in human V1 are proportional to average firing rates in monkey V1.

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Heeger, D., Huk, A., Geisler, W. et al. Spikes versus BOLD: what does neuroimaging tell us about neuronal activity? . Nat Neurosci 3, 631–633 (2000). https://doi.org/10.1038/76572

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