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Shining light on spiny matters

Nature Neuroscience volume 1, pages 93–94 (1998)Cite this article

Abstract

Two-photon microscopy might be the silver bullet to image calcium in individual dendritic spines, and can provide new information on calcium dynamics during synaptic activity.

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Figure 1: Spine cartoons.
Figure 2: Localization of excitation by two-photon absorption.

References

  1. Harris, K.M. & Kater, S.B. Ann. Rev. Neurosci. 17, 341–371 (1994)

    Article  CAS  Google Scholar 

  2. Muller, W. & Connor, J.A. Nature 354, 73–76 (1991)

    Article  CAS  Google Scholar 

  3. Yuste, R. & Denk, W. Nature 375, 682–684 (1995)

    Article  CAS  Google Scholar 

  4. Denk, W., Sugimori, M. & Llinas, R. Proc. Natl. Acad. Sci. USA 92, 8279– 8282 (1995)

    Article  CAS  Google Scholar 

  5. Svoboda, K., Tank, D.W. & Denk, W. Science 272, 716–719 ( 1996)

    Article  CAS  Google Scholar 

  6. Schiller, J., Schiller, Y. & Clapham, D.E. Nature Neurosci. 1, 114–118 (1998)

    Article  CAS  Google Scholar 

  7. Denk, W., Strickler, J.H. & Webb, W.W. Science 248, 73–76 ( 1990)

    Article  CAS  Google Scholar 

  8. Denk, W. & Svoboda, K. Neuron 18, 351– 357 (1997)

    Article  CAS  Google Scholar 

  9. Bliss, T.V.P. & Collinridge, G.L. Nature 361, 31–39 (1993)

    Article  CAS  Google Scholar 

  10. Bourne, H.R. & Nicoll, R.A. Cell 72, 65–75 (1993)

    Article  Google Scholar 

  11. Wieboldt, R., et al. Proc. Natl. Acad. USA 91, 8752–8756 (1994)

    Article  CAS  Google Scholar 

  12. Braitenberg, V. & Schutz, A. Anatomy of the Cortex 1–249 (Springer Verlag, Berlin, 1991 )

    Google Scholar 

  13. Magee, J.C. & Johnston, D. Science 275, 209–213 (1997)

    Article  CAS  Google Scholar 

  14. Hoffman, D.A., Magee, J.C., Colbert, C.M. & Johnston, D. Nature 287, 869–875 ( 1997)

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Center for Learning and Memory at the Cold Spring Harbor Laboratories, 1 Bungtown Road, Cold Spring Harbor, 11724, NY, USA

    Karel Svoboda

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  1. Karel Svoboda
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Correspondence to Karel Svoboda.

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Svoboda, K. Shining light on spiny matters. Nat Neurosci 1, 93–94 (1998). https://doi.org/10.1038/339

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