Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cocaine abuse: hard knocks for the dopamine hypothesis?

Abstract

The idea that cocaine's reinforcing effects are due to its action at the dopamine transporter is challenged by a new finding that mice lacking this protein self-administer cocaine.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Dopamine synapse in wild-type and DAT-knockout mice.
Figure 2: Dopamine's role in cocaine's mechanism of action, and a possible alternative in DAT-knockout mice.
Figure 3: Actions of cocaine at neural transporters in normal rats and DAT-knockout mice.

References

  1. Giros, B., Jaber, M., Jones, S.R., Wightman, R.M. & Caron, M.G. Nature 379, 606– 612 (1996)

    CAS  Article  Google Scholar 

  2. Mello, N.K. & Negus, S.S. Neuropsychopharmacology 14, 375–424 (1996)

    CAS  Article  Google Scholar 

  3. Roberts, D.C.S., Koob, G.F., Klonoff, P. & Fibiger, H.C. Pharmacol. Biochem. Behav. 12, 781–787 ( 1980)

    CAS  Article  Google Scholar 

  4. Caine, S.B. & Koob, G.F. J. Exp. Anal. Behav. 61, 213–221 (1994)

    CAS  Article  Google Scholar 

  5. Roberts, D.C.S., Loh, E.A., Baker, G.B. & Vickers, G. Pharmacol. Biochem. Behav. 49, 177–182 ( 1994)

    CAS  Article  Google Scholar 

  6. Bergman, J., Madras, B.K., Johnson, S.E. & Spealman, R.D. J. Pharmacol. Exp. Ther. 251, 150–155 (1989)

    CAS  PubMed  Google Scholar 

  7. Woolverton, W.L., Goldberg, L.I. & Ginos, J.Z. J. Pharmacol. Exp. Ther. 230, 678–683 (1984)

    CAS  PubMed  Google Scholar 

  8. Caine, S.B. & Koob, G.F. Behav. Pharmacol. 6, 333–347 (1995)

    CAS  Article  Google Scholar 

  9. Parsons, L.H., Weiss, F., & Koob, G.F. Psychopharmacology 128, 150–160 (1996)

    CAS  Article  Google Scholar 

  10. Benloucif, S., Keegan, M.J. & Galloway, M.P. J. Pharmacol. Exp. Ther. 265, 373 –377 (1993)

    CAS  PubMed  Google Scholar 

  11. Cameron, D.L. & Williams, J.T. J. Neurosci. 14, 6763–6767 (1994)

    CAS  Article  Google Scholar 

  12. Boulenguez, P. et al. Neuropharmacology 35, 1521–1529 (1996)

    CAS  Article  Google Scholar 

  13. Xu, M. et al. Cell 79, 945–955 ( 1994)

    CAS  Article  Google Scholar 

  14. Rocha, B., Ator, R., Emmett-Oglesby, M. & Hen, R. Pharmacol. Biochem. Behav. 57, 407–412 ( 1997)

    CAS  Article  Google Scholar 

  15. Parsons, L.H., Koob, G.F. & Weiss, F.J. Pharmacol. Exp. Ther. 274, 1182–1191 (1995)

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to S. Barak Caine.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Caine, S. Cocaine abuse: hard knocks for the dopamine hypothesis?. Nat Neurosci 1, 90–92 (1998). https://doi.org/10.1038/335

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/335

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing