Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

How serotonin gates olfactory information flow

Nature Neuroscience volume 12, pages 673–675 (2009)Cite this article

The olfactory bulb is densely innervated by serotonergic fibers. A study now shows that serotonin activates periglomerular interneurons, which release GABA to reduce transmitter release from olfactory sensory neurons.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Serotonergic control of odor inputs to the olfactory bulb.

References

  1. Petzold, G.C., Hagiwara, A. & Murthy, V.N. Nat. Neurosci. 12, 784–791 (2009).

    Article  CAS  Google Scholar 

  2. Bartolomé, M.V. & Gil-Loyzaga, P. Int. Tinnitus J. 11, 119–125 (2005).

    PubMed  Google Scholar 

  3. Sheibani, V. & Farazifard, R. Brain Res. Bull. 68, 430–435 (2006).

    Article  Google Scholar 

  4. Dong, W.Q., Qiao, J.T., Skolnick, M. & Dafny, N. Int. J. Neurosci. 57, 123–140 (1991).

    Article  CAS  Google Scholar 

  5. Chiang, C.Y., Hu, J.W., Dostrovsky, J.O. & Sessle, B.J. Brain Res. 485, 371–381 (1989).

    Article  CAS  Google Scholar 

  6. Von Baumgarten, R., Bloom, F.E., Oliver, A.P. & Salmoiraghi, G.C. Pflugers Arch. 277, 125–140 (1963).

    Article  Google Scholar 

  7. Bloom, F.E., Costa, E. & Salmoiraghi, G.C. J. Pharmacol. Exp. Ther. 146, 16–23 (1964).

    CAS  PubMed  Google Scholar 

  8. Hardy, A., Palouzier-Paulignan, B., Duchamp, A., Royet, J.P. & Duchamp-Viret, P. Neuroscience 131, 717–731 (2005).

    Article  CAS  Google Scholar 

  9. Allers, K.A. & Sharp, T. Neuroscience 122, 193–204 (2003).

    Article  CAS  Google Scholar 

  10. Mainen, Z.F. Soc. Neurosci. Abstr. 541.3 (2007).

  11. Gehlert, D.R., Gackenheimer, S.L., Wong, D.T. & Robertson, D.W. Brain Res. 553, 149–154 (1991).

    Article  CAS  Google Scholar 

  12. Ranade, S. & Mainen, Z.F. Soc. Neurosci. Abstr. 531.8 (2004).

  13. Kepecs, A., Uchida, N. & Mainen, Z.F. J. Neurophysiol. 98, 205–213 (2007).

    Article  Google Scholar 

  14. Verhagen, J.V., Wesson, D.W., Netoff, T.I., White, J.A. & Wachowiak, M. Nat. Neurosci. 10, 631–639 (2007).

    Article  CAS  Google Scholar 

  15. Bonham, A.C. Respir. Physiol. 101, 219–230 (1995).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Champalimaud Neuroscience Programme, Instituto Gulbenkian de Ciência, Oeiras, Portugal

    Guillaume P Dugué & Zachary F Mainen

Authors
  1. Guillaume P Dugué
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Zachary F Mainen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dugué, G., Mainen, Z. How serotonin gates olfactory information flow. Nat Neurosci 12, 673–675 (2009). https://doi.org/10.1038/nn0609-673

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn0609-673

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing