The orientation of the mitotic spindle determines whether divisions of the polarized neural progenitors in the ventricular zone cause their expansion or lead to neurogenesis. A guanine nucleotide exchange factor for the small GTPase RhoA is now shown to tip this balance in favor of neurogenesis.
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Marzesco, AM., Mora-Bermudez, F. & Huttner, W. Neurogenesis in G minor. Nat Neurosci 12, 669–671 (2009). https://doi.org/10.1038/nn0609-669
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DOI: https://doi.org/10.1038/nn0609-669
