Stress hormones and brain aging: adding injury to insult?

Abstract

Glucocorticoids are known to promote the death of neurons in a variety of experimental systems. A new study suggests that they may also contribute to hippocampal atrophy during normal human aging.

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Figure 1: The glucocorticoid hypothesis of cognitive decline in aging.
Figure 2

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Porter, N., Landfield, P. Stress hormones and brain aging: adding injury to insult?. Nat Neurosci 1, 3–4 (1998). https://doi.org/10.1038/196

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