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Cheesecake-eating rats and the question of food addiction

Rats given extended access to high-fat high-sugar food show behavioral and physiological changes that are similar to those caused by drugs of abuse. However, parallels between drug and food “addiction” should be drawn with caution.

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Figure 1: Prolonged access to cafeteria food causes persistent elevations in threshold for BSR: comparison with drugs of abuse.

References

  1. Avena, N.M., Rada, P. & Hoebel, B.G. Neurosci. Biobehav. Rev. 32, 20–39 (2008).

    CAS  Article  Google Scholar 

  2. Johnson, P.M. & Kenny, P.J. Nat. Neurosci. 13, 635–641 (2010).

    CAS  Article  Google Scholar 

  3. Ahmed, S.H., Kenny, P.J., Koob, G.F. & Markou, A. Nat. Neurosci. 5, 625–626 (2002).

    CAS  Article  Google Scholar 

  4. Kenny, P.J., Chen, S.A., Kitamura, O., Markou, A. & Koob, G.F. J. Neurosci. 26, 5894–5900 (2006).

    CAS  Article  Google Scholar 

  5. Epping-Jordan, M.P., Watkins, S.S., Koob, G.F. & Markou, A. Nature 393, 76–79 (1998).

    CAS  Article  Google Scholar 

  6. Markou, A. & Koob, G.F. Neuropsychopharmacology 4, 17–26 (1991).

    CAS  PubMed  Google Scholar 

  7. Schulteis, G., Markou, A., Cole, M. & Koob, G.F. Proc. Natl. Acad. Sci. USA 92, 5880–5884 (1995).

    CAS  Article  Google Scholar 

  8. Volkow, N.D. & Wise, R.A. Nat. Neurosci. 8, 555–560 (2005).

    CAS  Article  Google Scholar 

  9. Dalley, J.W. et al. Science 315, 1267–1270 (2007).

    CAS  Article  Google Scholar 

  10. Lenoir, M., Serre, F., Cantin, L. & Ahmed, S.H. PLoS One 2, e698 (2007).

    Article  Google Scholar 

  11. Cottone, P. et al. Proc. Natl. Acad. Sci. USA 106, 20016–20020 (2009).

    CAS  Article  Google Scholar 

  12. Nair, S.G., Adams-Deutsch, T., Epstein, D.H. & Shaham, Y. Prog. Neurobiol. 89, 18–45 (2009).

    CAS  Article  Google Scholar 

  13. Wonderlich, S.A., Gordon, K.H., Mitchell, J.E., Crosby, R.D. & Engel, S.G. Int. J. Eat. Disord. 42, 687–705 (2009).

    Article  Google Scholar 

  14. Major, G.C., Doucet, E., Trayhurn, P., Astrup, A. & Tremblay, A. Int. J. Obes. (Lond.) 31, 204–212 (2007).

    CAS  Article  Google Scholar 

  15. Heindel, J.J. & vom Saal, F.S. Mol. Cell. Endocrinol. 304, 90–96 (2009).

    CAS  Article  Google Scholar 

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Correspondence to Yavin Shaham.

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Epstein, D., Shaham, Y. Cheesecake-eating rats and the question of food addiction. Nat Neurosci 13, 529–531 (2010). https://doi.org/10.1038/nn0510-529

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