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Bottoms up: transduction channels at tip link bases

A study now demonstrates that the transduction channel responsible for converting sound to neural signals in the mammalian cochlea is excluded from the tallest row of stereocilia and is instead more likely in the bottom row.

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Figure 1: Ca2+ entry during mechanotransduction.
Figure 2: Hypothetical mechanisms of transduction-channel activation.

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Spinelli, K., Gillespie, P. Bottoms up: transduction channels at tip link bases. Nat Neurosci 12, 529–530 (2009). https://doi.org/10.1038/nn0509-529

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