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Fire in the hole: pore dilation of the capsaicin receptor TRPV1

Nature Neuroscience volume 11, pages 528–529 (2008)Cite this article

The capsaicin receptor TRPV1 is important in pain sensation. A new study suggests that this nonselective cation channel shows dynamic alterations in ion permeability, which may contribute to mechanisms of pain hypersensitivity.

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Figure 1: The TRPV1 pore dilation model proposed by Chung et al.3

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Authors and Affiliations

  1. Department of Physiology, University of California, San Francisco, 600 16th Street, San Francisco, 94143, California, USA

    Diana Bautista & David Julius

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  1. Diana Bautista
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  2. David Julius
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Bautista, D., Julius, D. Fire in the hole: pore dilation of the capsaicin receptor TRPV1. Nat Neurosci 11, 528–529 (2008). https://doi.org/10.1038/nn0508-528

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