Fire in the hole: pore dilation of the capsaicin receptor TRPV1

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The capsaicin receptor TRPV1 is important in pain sensation. A new study suggests that this nonselective cation channel shows dynamic alterations in ion permeability, which may contribute to mechanisms of pain hypersensitivity.

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Figure 1: The TRPV1 pore dilation model proposed by Chung et al.3

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Bautista, D., Julius, D. Fire in the hole: pore dilation of the capsaicin receptor TRPV1. Nat Neurosci 11, 528–529 (2008) doi:10.1038/nn0508-528

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