How I learned to stop worrying and love calcineurin

Article metrics

Many kinases have been implicated in memory formation, but a new study suggests that a phosphatase, calcineurin, is important for the long-lasting nature of emotional memories by making them resistant to extinction.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: The role of calcineurin in conditioned taste aversion.

Katie Ris-Vicari

References

  1. 1

    Baumgärtel, K. et al. Nat. Neurosci. 11, 572–578 (2008).

  2. 2

    Garcia, J., Kimeldorf, D.J. & Koelling, R.A. Science 122, 157–158 (1955).

  3. 3

    Welzl, H., D'Adamo, P. & Lipp, H.P. Behav. Brain Res. 125, 205–213 (2001).

  4. 4

    Yamamoto, T., Shimura, T., Sako, N., Yasoshima, Y. & Sakai, N. Behav. Brain Res. 65, 123–137 (1994).

  5. 5

    Havekes, R., Nijholt, I.M., Visser, A.K., Eisel, U.L. & Van der Zee, E.A. Neurobiol. Learn. Mem. published online, doi:10.1016/j.nlm.2007.08.003 (18 September 2007).

  6. 6

    Lin, C.H. et al. J. Neurosci. 23, 1574–1579 (2003).

  7. 7

    Lamprecht, R., Hazvi, S. & Dudai, Y. J. Neurosci. 17, 8443–8450 (1997).

  8. 8

    Barad, M., Gean, P.W. & Lutz, B. Biol. Psychiatry 60, 322–328 (2006).

  9. 9

    Stafstrom-Davis, C.A. et al. Learn. Mem. 8, 272–278 (2001).

  10. 10

    Winder, D.G. & Sweatt, J.D. Nat. Rev. Neurosci. 2, 461–474 (2001).

  11. 11

    Kim, J. et al. Proc. Natl. Acad. Sci. USA 104, 20955–20960 (2007).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Sindreu, C., Storm, D. How I learned to stop worrying and love calcineurin. Nat Neurosci 11, 527–528 (2008) doi:10.1038/nn0508-527

Download citation