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Eph–ephrin promiscuity is now crystal clear

Nature Neuroscience volume 7, pages 417418 (2004) | Download Citation

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The ephrin subclasses A and B are not thought to interact much with each other's receptors. A study in this issue now shows that ephrin-A5 can signal through the EphB2 receptor, toppling this dogma. The crystal structure of the EphB2–ephrin-A5 complex clarifies the molecular features of this interaction and suggests new hypotheses for the mechanism of ephrin receptor signaling.

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Affiliations

  1. Elena B. Pasquale is at the Burnham Institute, La Jolla, California 92037, USA and the Department of Pathology, University of California at San Diego, La Jolla, California 92093, USA. elenap@burnham.org

    • Elena B Pasquale

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DOI

https://doi.org/10.1038/nn0504-417

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