Vasopressin release increases late in sleep. Suprachiasmatic clock neurons modulate osmosensory synapses onto vasopressin neurons to facilitate osmoregulated vasopressin release, reports a study in this issue. This explains the increased late-night vasopressin release, and such facilitation prevents dehydration during sleep.
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Colwell, C. Preventing dehydration during sleep. Nat Neurosci 13, 403–404 (2010). https://doi.org/10.1038/nn0410-403
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DOI: https://doi.org/10.1038/nn0410-403