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Neuronal communication: a detailed balancing act

What controls the functional connections between sending and receiving neurons? A new model suggests that each receiver circuit has a local switch that is controlled by the balance between excitation and inhibition.

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Figure 1: Gating neuronal inputs through detailed balance of excitation and inhibition.

References

  1. Vogels, T.P. & Abott, L.F. Nat. Neurosci. 12, 483–491 (2009).

    Article  CAS  Google Scholar 

  2. Shadlen, M.N. & Newsome, W.T. Curr. Opin. Neurobiol. 4, 569–579 (1994).

    Article  CAS  Google Scholar 

  3. Troyer, T.W. & Miller, K.D. Neural Comput. 9, 971–983 (1997).

    Article  CAS  Google Scholar 

  4. Salinas, E. & Sejnowski, T.J. J. Neurosci. 20, 6193–6209 (2000).

    Article  CAS  Google Scholar 

  5. van Vreeswijk, C. & Sompolinsky, H. Science 274, 1724–1726 (1996).

    Article  CAS  Google Scholar 

  6. Shu, Y., Hasenstaub, A. & McCormick, D.A. Nature 423, 288–293 (2003).

    Article  CAS  Google Scholar 

  7. Haider, B., Duque, A., Hasenstaub, A.R. & McCormick, D.A. J. Neurosci. 26, 4535–4545 (2006).

    Article  CAS  Google Scholar 

  8. Abeles, M. Corticonics: Neural Circuits of the Cerebral Cortex (Cambridge University Press, New York, 1991).

    Book  Google Scholar 

  9. Diesmann, M., Gewaltig, M.-O. & Aertsen, A. Nature 402, 529–533 (1999).

    Article  CAS  Google Scholar 

  10. van Rossum, M.C.W., Turrigiano, G.G. & Nelson, S.B. J. Neurosci. 22, 1956–1966 (2002).

    Article  CAS  Google Scholar 

  11. Felleman, D.J. & Van Essen, D.C. Cereb. Cortex 1, 1–47 (1991).

    Article  CAS  Google Scholar 

  12. Kumar, A., Rotter, S. & Aertsen, A. J. Neurosci. 28, 5268–5280 (2008).

    Article  CAS  Google Scholar 

  13. Vogels, T.P. & Abbott, L.F. J. Neurosci. 25, 10786–10795 (2005).

    Article  CAS  Google Scholar 

  14. Olshausen, B.A., Anderson, C.H. & Van Essen, D.C. J. Neurosci. 13, 4700–4719 (1993).

    Article  CAS  Google Scholar 

  15. Salinas, E. BMC Neurosci. 5, 47 (2004).

    Article  Google Scholar 

Download references

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Salinas, E. Neuronal communication: a detailed balancing act. Nat Neurosci 12, 372–374 (2009). https://doi.org/10.1038/nn0409-372

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