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Proteoglycans specify Sonic Hedgehog effect

Nature Neuroscience volume 12, pages 371372 (2009) | Download Citation

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How can the multifunctional factor Sonic Hedgehog (SHH) elicit specific responses from its target cells? A study now pinpoints proteoglycans as crucial anchors and modulators of SHH signaling, eliciting a proliferation response.

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Author information

Affiliations

  1. Catherine Vaillant is a member of the Developmental Genetics group, Department of Biomedicine, University of Basel, Basel, Switzerland. c.vaillant@unibas.ch

    • Catherine Vaillant
  2. Denis Monard is at the Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland. monard@fmi.ch

    • Denis Monard

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DOI

https://doi.org/10.1038/nn0409-371

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