Neural stem cells transition through several progenitor stages before finally generating postmitotic neurons. New work shows that one of these steps, the generation of neuroblasts from transient amplifying precursors in the adult subventricular zone, requires downregulation of the transcription factor Sox9 by the microRNA miR-124.
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References
Cheng, L., Pastrana, E., Tavazoie, M. & Doetsch, F. Nat. Neurosci. 12, 399–408 (2009).
Alvarez-Buylla, A. & Lim, D.A. Neuron 41, 683–686 (2004).
Namihira, M., Kohyama, J., Abematsu, M. & Nakashima, K. Epigenetic mechanisms regulating fate specification of neural stem cells. Philos. Trans. R Soc. Lond. B Biol. Sci. 363, 2099–2109 (2008).
Makeyev, E.V. & Maniatis, T. Science 319, 1789–1790 (2008).
Lagos-Quintana, M. et al. Curr. Biol. 12, 735–739 (2002).
Zeng, Y. Mol. Pharmacol. 75, 259–264 (2009).
Visvanathan, J., Lee, S., Lee, B., Lee, J.W. & Lee, S.K. Genes Dev. 21, 744–749 (2007).
Cao, X., Pfaff, S.L. & Gage, F.H. Genes Dev. 21, 531–536 (2007).
Doetsch, F., Garcia-Verdugo, J.M. & Alvarez-Buylla, A. Proc. Natl. Acad. Sci. USA 96, 11619–11624 (1999).
Stolt, C.C. et al. Genes Dev. 17, 1677–1689 (2003).
Nowak, J.A., Polak, L., Pasolli, H.A. & Fuchs, E. Cell Stem Cell 3, 33–43 (2008).
Bastide, P. et al. J. Cell Biol. 178, 635–648 (2007).
Lim, L.P. et al. Nature 433, 769–773 (2005).
Bartel, D.P. & Chen, C.Z. Nat. Rev. Genet. 5, 396–400 (2004).
Conaco, C., Otto, S., Han, J.J. & Mandel, G. Proc. Natl. Acad. Sci. USA 103, 2422–2427 (2006).
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Shen, Q., Temple, S. Fine control: microRNA regulation of adult neurogenesis. Nat Neurosci 12, 369–370 (2009). https://doi.org/10.1038/nn0409-369
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DOI: https://doi.org/10.1038/nn0409-369
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