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Even chromatin gets the blues

Antidepressants take a few weeks to act, and their effects can extend for months after the drugs are discontinued. Tsankova et al. suggest a possible molecular basis for these effects, by showing that stress and the antidepressant imipramine induce modifications of chromatin to produce more or less repressive states for gene expression.

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Figure 1: Model for states of chromatin surrounding the BDNF promoter.


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Hyman, S. Even chromatin gets the blues. Nat Neurosci 9, 465–466 (2006).

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