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A proposed mechanism of ALS fails the test in vivo

Nature Neuroscience volume 5, pages 287288 (2002) | Download Citation

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In contrast to prevailing hypotheses, a genetic study shows that the toxic gain of function associated with mutant superoxide dismutase in familial amyotropic lateral sclerosis is unlikely to be due to changes in its oxidative activity causing an increase in free radicals.

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Affiliations

  1. Harry Orr is in the Department of Laboratory Medicine and Pathology and the Institute of Human Genetics at the University of Minnesota, 5-220A Moos Tower, Minneapolis, Minnesota 55455, USA. orrxx002@maroon.tc.umn.edu

    • Harry T. Orr

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DOI

https://doi.org/10.1038/nn0402-287

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