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Lighting up the hypothalamus: coordinated control of feeding behavior

A new optogenetics study finds that stimulation of pro-opiomelanocortin (POMC) and agouti-related peptide (AGRP) neurons acutely regulates feeding behavior. AGRP-induced hyperphagia is independent of melanocortin signaling.

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Figure 1: Optogenetics defines feeding behavior in the arcuate nucleus of the hypothalamus.

Marina Corral


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Correspondence to Kevin W Williams or Joel K Elmquist.

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Williams, K., Elmquist, J. Lighting up the hypothalamus: coordinated control of feeding behavior. Nat Neurosci 14, 277–278 (2011).

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