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Myelin maintenance: axonal support required

Axonal integrity depends on an intact myelin sheath, but the role of the axon in myelin maintenance is more mysterious. A new study reports that preservation of the myelin sheath requires neuronal expression of the enigmatic prion protein.

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Figure 1: Myelin maintenance by PrPc.


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Correspondence to Brian Popko.

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Popko, B. Myelin maintenance: axonal support required. Nat Neurosci 13, 275–277 (2010).

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