Calcium channels diversify their signaling portfolio

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Sensory neurons express sets of ion channels that contribute to pain transmission. A new study finds that a sensory neuron–specific exon encodes a molecular switch that recruits other signaling pathways to N-type Ca2+ channels.

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Figure 1: Possible functional consequences of the differential modulation of exons 37a and 37b.

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Ikeda, S., Dunlap, K. Calcium channels diversify their signaling portfolio. Nat Neurosci 10, 269–271 (2007) doi:10.1038/nn0307-269

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