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PEDF: bridging neurovascular interactions in the stem cell niche

Stem cells are defined by their ability to self-renew. Adult brain stem cells divide slowly, and it is unclear how their division is regulated. A new study identifies PEDF as a growth factor that promotes adult stem cell self-renewal.

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Figure 1: Schematic representation of identified functional domains of PEDF, including major phosphorylation sites and domains known to be critical for interactions with extracellular matrix.


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Pumiglia, K., Temple, S. PEDF: bridging neurovascular interactions in the stem cell niche. Nat Neurosci 9, 299–300 (2006).

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