Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Plateau properties in pain pathways

Nature Neuroscience volume 6, pages 210–212 (2003)Cite this article

A new paper shows that excitatory and inhibitory neuromodulators can change the firing properties of spinal cord neurons, with implications for pain processing.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Three different firing patterns found in deep dorsal horn neurons.
Figure 2: Cells with the three firing patterns shown in Fig. 1 have different responses to the same input.

References

  1. Derjean, D. et al. Nat. Neurosci. 6, 274–281 (2003).

    Article  CAS  Google Scholar 

  2. Marder, E. & Bucher, D. Curr. Biol. 11, R986–R996 (2001).

    Article  CAS  Google Scholar 

  3. Marder, E. Curr. Biol. 1, 326–327 (1991).

    Article  CAS  Google Scholar 

  4. Kiehn, O. Trends Neurosci. 14, 68–73 (1991).

    Article  CAS  Google Scholar 

  5. Hille, B. Ion Channels of Excitable Membranes (Sinauer, Sunderland, Massachusettts, 2001).

    Google Scholar 

  6. Le Masson, G., Renaud-Le Masson, S., Debay, D. & Bal, T. Nature 417, 854–858 (2002).

    Article  CAS  Google Scholar 

  7. Sharp, A.A., O'Neil, M.B., Abbott, L.F. & Marder, E. J. Neurophysiol. 69, 992–995 (1993).

    Article  CAS  Google Scholar 

  8. Pinsker, H.M. J. Neurophysiol. 40, 527–543 (1977).

    Article  CAS  Google Scholar 

  9. Morisset, V. & Nagy, F. Eur. J. Neurosci. 12, 3087–3095 (2000).

    Article  CAS  Google Scholar 

  10. Marder, E. & Calabrese, R.L. Physiol. Rev. 76, 687–717 (1996).

    Article  CAS  Google Scholar 

  11. Getting, P.A. Annu. Rev. Neurosci. 12, 185–204 (1989).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The author is at the Volen Center and Dept. of Biology, Brandeis University, 415 South Street, Waltham, 02454, Massachusetts, USA

    Eve Marder

Authors
  1. Eve Marder
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Marder, E. Plateau properties in pain pathways. Nat Neurosci 6, 210–212 (2003). https://doi.org/10.1038/nn0303-210

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn0303-210

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing