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Cold emerging from the fog

Nature Neuroscience volume 5, pages 189–190 (2002)Cite this article

Proposed mechanisms for the sensation of cold have focused on single proteins. A paper in this issue reports that cold trans-duction depends on a complex interplay among ion channels.

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Figure 1: Multiple ion channels contribute to cold-induced firing of action potentials in cold-sensitive neurons and pharmacologically modified cold-insensitive neurons.

References

  1. Christensen, B. N. & Perl, E. R. J. Neurophysiol. 33, 293–307 (1970).

    Article  CAS  PubMed  Google Scholar 

  2. Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D. & Julius, D. Nature 389, 816–824 (1997).

    Article  CAS  PubMed  Google Scholar 

  3. Viana, F., de la Pena, E. & Belmonte, C. Nature Neurosci. 5, 254–260 (2002).

    Article  CAS  PubMed  Google Scholar 

  4. Kenshalo, D. R. & Duclaux, R. J. Neurophysiol. 40, 319–332 (1977).

    Article  CAS  PubMed  Google Scholar 

  5. Simone, D. A. & Kajander, K. C. J. Neurophysiol. 77, 2049–2060 (1997).

    Article  CAS  PubMed  Google Scholar 

  6. Clapham, D. E. Neuron 21, 5–7 (1998).

    Article  CAS  PubMed  Google Scholar 

  7. Maingret, F. et al. EMBO J. 19, 2483–2491 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Askwith, C. C., Benson, C. J., Welsh, M. J. & Snyder, P. M. Proc. Natl Acad. Sci. USA 98, 6459–6463 (2001).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Reid, G. & Flonta, M. L. Nature 413, 480 (2001).

    Article  CAS  PubMed  Google Scholar 

  10. McKemy, D. D., Neuhausser, W. M. & Julius, D. Nature (in press).

  11. Ludwig, A., Zong, X., Jeglitsch, M., Hofmann, F. & Biel, M. Nature 393, 587–591 (1998).

    Article  CAS  PubMed  Google Scholar 

  12. Okazawa, M., Terauchi, T., Shiraki, T., Matsumura, K. & Kobayashi, S. Neuroreport 11, 2151–2155 (2000).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Dept. of Physiology & Cellular Biology and the Center for Neurobiology and Behavior, 630 West 168th Street, Rm. 1109BB, New York, 10032, New York, USA

    Amy B. MacDermott

  2. Departmentt of Pharmacology, Emory University, 1510 Clifton Road, Atlanta, 30322, Georgia, USA

    C. Justin Lee

Authors
  1. Amy B. MacDermott
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  2. C. Justin Lee
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MacDermott, A., Lee, C. Cold emerging from the fog. Nat Neurosci 5, 189–190 (2002). https://doi.org/10.1038/nn0302-189

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