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Two faces for an opioid peptide—and more receptors for pain research

Nature Neuroscience volume 5, pages 185186 (2002) | Download Citation

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A new study reports the cloning of a family of 'orphan' G-protein-coupled receptors that are localized in human and rat small sensory neurons. These receptors are activated by a peptide derived from preproenkephalin A and may be involved in modulating nociception.

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Author information

Affiliations

  1. IGBMC, 1 rue L:aurent Fires, 67400 Illkirch, France. briki@esbs.u-strasbg.fr

    • Frédéric Simonin
    •  & Brigitte L. Kieffer

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DOI

https://doi.org/10.1038/nn0302-185

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