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Two faces for an opioid peptide—and more receptors for pain research

Nature Neuroscience volume 5, pages 185–186 (2002)Cite this article

A new study reports the cloning of a family of 'orphan' G-protein-coupled receptors that are localized in human and rat small sensory neurons. These receptors are activated by a peptide derived from preproenkephalin A and may be involved in modulating nociception.

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Figure 1: Schematic diagram of pain pathways from the periphery to the CNS.

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References

  1. Lembo, P. M. C. et al. Nature Neurosci. 5, 201–209 (2002).

    Article  CAS  Google Scholar 

  2. Akil, H. et al. Annu. Rev. Neurosci. 7, 223–255 (1984).

    Article  CAS  Google Scholar 

  3. Kieffer, B. L. Cell. Mol. Neurobiol. 15, 615–635 (1995).

    Article  CAS  Google Scholar 

  4. Mansour, A., Fox, C. A., Akil, H. & Watson, S. J. Trends Neurosci. 18, 22–29 (1995).

    Article  CAS  Google Scholar 

  5. Rossier, J. in Opioids I. Handbook of Experimental Pharmacology (eds. Herz, A.) 423–441 (Springer, Berlin, 1993).

    Google Scholar 

  6. Lee, D. K., George, S. R., Evans, J. F., Lynch, K. R. & O'Dowd, B. F. Curr. Opin. Pharmacol. 1, 31–39 (2001).

    Article  CAS  Google Scholar 

  7. Civelli, O. et al. Trends Neurosci. 24, 230–237 (2001).

    Article  CAS  Google Scholar 

  8. Woods, J. A., Shahabi, N. A. & Sharp, B. M. Life Sci. 60, 573–586 (1997).

    Article  CAS  Google Scholar 

  9. Van den Bergh, P., Rozing, J. & Nagelkerken, L. Lymphokine Cytok. Res. 13, 63–69 (1994).

    CAS  Google Scholar 

  10. Dong, X., Han, S., Zylka, M. J., Simon, M. I. & Anderson, D. J. Cell 106, 619–632 (2001).

    Article  CAS  Google Scholar 

  11. Snider, W. D. & McMahon, S. B. Neuron 20, 629–632 (1998).

    Article  CAS  PubMed Central  Google Scholar 

  12. Julius, D. & Basbaum, A. I. Nature 413, 203–210 (2001).

    Article  CAS  PubMed Central  Google Scholar 

  13. Mantyh, P. W. et al. Science 278, 275–279 (1997).

    Article  CAS  Google Scholar 

  14. Malmberg, A. B., Chen, C., Tonegawa, S. & Basbaum, A. I. Science 278, 279–283 (1997).

    Article  CAS  Google Scholar 

  15. Nichols, M. L. et al. Science 286, 1558–1561 (1999).

    Article  CAS  Google Scholar 

Download references

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  1. IGBMC, 1 rue L:aurent Fires, Illkirch, 67400, France

    Frédéric Simonin & Brigitte L. Kieffer

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  1. Frédéric Simonin
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  2. Brigitte L. Kieffer
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Simonin, F., Kieffer, B. Two faces for an opioid peptide—and more receptors for pain research. Nat Neurosci 5, 185–186 (2002). https://doi.org/10.1038/nn0302-185

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