Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Too much Sonic, too few neurons

The floor plate can generate neurons, but does so only in the midbrain. New work shows that Shh suppresses floor plate neurogenesis, and that in the midbrain, Wnt downregulates Shh expression via canonical signaling through β-catenin.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Both hindbrain and midbrain floor plate are dependent on Shh for floor plate induction.

References

  1. Placzek, M. & Briscoe, J. Nat. Rev. Neurosci. 6, 230–240 (2005).

    Article  CAS  Google Scholar 

  2. Charron, F., Stein, E., Jeong, J., McMahon, A.P. & Tessier-Lavigne, M. Cell 113, 11–23 (2003).

    Article  CAS  Google Scholar 

  3. Kittappa, R., Chang, W.W., Awatramani, R.B. & McKay, R.D. PLoS Biol. 5, e325 (2007).

    Article  Google Scholar 

  4. Ono, Y. et al. Development 134, 3213–3225 (2007).

    Article  CAS  Google Scholar 

  5. Joksimovic et al. Nat. Neurosci. 12, 125–131 (2009).

    Article  CAS  Google Scholar 

  6. Epstein, D.J., McMahon, A.P. & Joyner, A.L. Development 126, 281–292 (1999).

    CAS  PubMed  Google Scholar 

  7. Prakash, N. et al. Development 133, 89–98 (2006).

    Article  CAS  Google Scholar 

  8. Falk, S. et al. Cell Stem Cell. 2, 472–483 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fasano, C., Studer, L. Too much Sonic, too few neurons. Nat Neurosci 12, 107–108 (2009). https://doi.org/10.1038/nn0209-107

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn0209-107

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing