New work in this issue shows that one principal endocannabinoid, anandamide, directly inhibits the synthesis of another, 2-arachidonoylglycerol. This finding could explain a number of puzzling observations in the endocannabinoid field.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Role of the endocannabinoid system in obesity induced by neuropeptide Y overexpression in noradrenergic neurons
Nutrition & Diabetes Open Access 27 April 2015
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Devane, W.A. et al. Science 258, 1946–1949 (1992).
Johnson, D.E., Heald, S.L., Dally, R.D. & Janis, R.A. Prostaglandins Leukot. Essent. Fatty Acids 48, 429–437 (1993).
Starowicz, K., Nigam, S. & Di Marzo, V. Pharmacol. Ther. 114, 13–33 (2007).
Maccarrone, M. et al. Nat. Neurosci. 11, 152–159 (2008).
Hashimotodani, Y., Ohno-Shosaku, T., Maejima, T., Fukami, K. & Kano, M. Neuropharmacology 54, 58–67 (2008).
Nomura, S., Fukaya, M., Tsujioka, T., Wu, D. & Watanabe, M. Eur. J. Neurosci. 25, 659–672 (2007).
Gulyas, A.I. et al. Eur. J. Neurosci. 20, 441–448 (2004).
Szabo, B. et al. J. Physiol. (Lond.) 577, 263–280 (2006).
van der Stelt, M. et al. EMBO J. 24, 3026–3037 (2005).
Valenti, M. et al. Cell. Mol. Life Sci. 61, 945–950 (2004).
Rubino, T. et al. Cereb. Cortex published online 7 October 2007 (10.1093/cercor/bhm161).
Cristino, L. et al. Neuroscience 139, 1405–1415 (2006).
Maione, S. et al. J. Pharmacol. Exp. Ther. 316, 969–982 (2006).
Kim, J. & Alger, B.E. Nat. Neurosci. 7, 697–698 (2004).
Jung, K.-M. et al. Mol. Pharmacol. 68, 1196–1202 (2005).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Di Marzo, V., Cristino, L. Why endocannabinoids are not all alike. Nat Neurosci 11, 124–126 (2008). https://doi.org/10.1038/nn0208-124
Issue Date:
DOI: https://doi.org/10.1038/nn0208-124
This article is cited by
-
Role of the endocannabinoid system in obesity induced by neuropeptide Y overexpression in noradrenergic neurons
Nutrition & Diabetes (2015)
-
Non-CB1, Non-CB2 Receptors for Endocannabinoids, Plant Cannabinoids, and Synthetic Cannabimimetics: Focus on G-protein-coupled Receptors and Transient Receptor Potential Channels
Journal of Neuroimmune Pharmacology (2010)