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Why endocannabinoids are not all alike

New work in this issue shows that one principal endocannabinoid, anandamide, directly inhibits the synthesis of another, 2-arachidonoylglycerol. This finding could explain a number of puzzling observations in the endocannabinoid field.

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Figure 1: Brain vanilloid versus cannabinoid receptors.

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Di Marzo, V., Cristino, L. Why endocannabinoids are not all alike. Nat Neurosci 11, 124–126 (2008). https://doi.org/10.1038/nn0208-124

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