Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Sleep: hitting the reset button

Many aspects of sleep, including the how and why, are still mysterious, especially its relationship to learning and memory. A new study suggests that sleep may serve to reset synaptic potentiation, linking it to homeostatic plasticity.

This is a preview of subscription content

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: The sleep state may provide an opportunity to reset synapses in the brain, depotentiating them back to baseline Awake episode is possible.

References

  1. 1

    Vyazovskiy, V.V., Cirelli, C., Pfister-Genskow, M., Faraguna, U. & Tononi, G. Nat. Neurosci. 11, 200–208 (2008).

    CAS  Article  Google Scholar 

  2. 2

    Blanco-Centurion, C. et al. J. Neurosci. 26, 8092–8100 (2006).

    CAS  Article  Google Scholar 

  3. 3

    Stickgold, R. & Walker, M.P. Sleep Med. 8, 331–343 (2007).

    Article  Google Scholar 

  4. 4

    Korman, M. et al. Nat. Neurosci. 10, 1206–1213 (2007).

    CAS  Article  Google Scholar 

  5. 5

    Huber, R., Ghilardi, M.F., Massimini, M. & Tononi, G. Nature 430, 78–81 (2004).

    CAS  Article  Google Scholar 

  6. 6

    Huber, R. et al. PLoS ONE 2, e276 (2007).

    Article  Google Scholar 

  7. 7

    Turrigiano, G. Curr. Opin. Neurobiol. 17, 318–324 (2007).

    CAS  Article  Google Scholar 

  8. 8

    Shepherd, J.D. & Huganir, R.L. Annu. Rev. Cell Dev. Biol. 23, 613–643 (2007).

    CAS  Article  Google Scholar 

  9. 9

    Maret, S. et al. Proc. Natl. Acad. Sci. USA 104, 20090–20095 (2007).

    CAS  Article  Google Scholar 

  10. 10

    Rao, Y. et al. J. Clin. Invest. 117, 4022–4033 (2007).

    CAS  Article  Google Scholar 

  11. 11

    Sherin, J.E., Shiromani, P.J., McCarley, R.W. & Saper, C.B. Science 271, 216–219 (1996).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Griffith, L., Rosbash, M. Sleep: hitting the reset button. Nat Neurosci 11, 123–124 (2008). https://doi.org/10.1038/nn0208-123

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing