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Defending the brain from estrogen

Nature Neuroscience volume 9, pages 155–156 (2006)Cite this article

Alpha-fetoprotein binds estrogens in the developing brain. A new paper shows that inhibiting estrogen rescues the brain masculinization found in female mice lacking this gene, suggesting that alpha-fetoprotein inhibits estrogen activity in females.

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Figure 1: Sexual differentiation of the brain.

Debbie Maizels

References

  1. Bakker, J. et al. Nat. Neurosci. 9, 220–226 (2006).

    Article  CAS  Google Scholar 

  2. Morris, J.A., Jordan, C.L. & Breedlove, S.M. Nat. Neurosci. 7, 1034–1039 (2004).

    Article  CAS  Google Scholar 

  3. Roselli, C.E. & Resko, J.A. Steroids 50, 495–508 (1987).

    Article  CAS  Google Scholar 

  4. Gorski, R.A. Am. J. Physiol. 205, 842–844 (1963).

    Article  CAS  Google Scholar 

  5. Whalen, R.E. & Nadler, R.D. Science 141, 273–274 (1963).

    Article  CAS  Google Scholar 

  6. Conley, A. & Hinshelwood, M. Reproduction 121, 685–695 (2001).

    Article  CAS  Google Scholar 

  7. McEwen, B.S., Plapinger, L., Chaptal, C., Gerlach, J. & Wallach, G. Brain Res. 96, 400–406 (1975).

    Article  CAS  Google Scholar 

  8. Blizard, D. & Denef, C. Physiol. Behav. 11, 65–69 (1973).

    Article  CAS  Google Scholar 

  9. Sodersten, P. J. Endocrinol. 70, 409–420 (1976).

    Article  CAS  Google Scholar 

  10. Gerall, A.A., Dunlap, J.L. & Hendricks, S.E. J. Comp. Physiol. Psychol. 82, 449–465 (1973).

    Article  CAS  Google Scholar 

  11. Leret, M.L., Molina-Holgado, F. & Gonzalez, M.I. Physiol. Behav. 55, 371–373 (1994).

    Article  CAS  Google Scholar 

  12. Denti, A. & Negroni, J.A. Acta Physiol. Lat. Am. 25, 99–106 (1975).

    CAS  PubMed  Google Scholar 

  13. Toran-Allerand, C.D. in Sex Differences in the Brain: the Relation Between Structure and Function (eds. De Vries, G.J., De Bruin, J.P.C., Uylings, H.B.M. & Corner, M.A.) 63–98 (Elsevier Science, Amsterdam, 1984).

    Book  Google Scholar 

  14. Toran-Allerand, C.D. Brain Res. 281, 213–217 (1982).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Neuroscience Program, Michigan State University, East Lansing, 48824-1101, Michigan, USA

    David A Puts, Cynthia L Jordan & S Marc Breedlove

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  1. David A Puts
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  2. Cynthia L Jordan
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  3. S Marc Breedlove
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Puts, D., Jordan, C. & Breedlove, S. Defending the brain from estrogen. Nat Neurosci 9, 155–156 (2006). https://doi.org/10.1038/nn0206-155

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