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The association between brain volume and intelligence is of genetic origin

Nature Neuroscience volume 5, pages 83–84 (2002)Cite this article

To the editor

The recent study by Thompson and colleagues1 reported high heritability of gray-matter volume in several cortical regions using voxel-based MRI techniques. Gray matter substantially correlated with general intelligence, or 'g'. These findings prompt three major questions: (i) is the high heritability specific to gray-matter volume, (ii) is the correlation with g specific to gray-matter volume and (iii) is the correlation between gray-matter volume and g of genetic or environmental origin?

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References

  1. Thompson, P. M. et al. Nat. Neurosci. 4, 1253–1258 (2001).

    Article  CAS  PubMed  Google Scholar 

  2. Baaré, W. F. C. et al. Cereb. Cortex 11, 816–824 (2001).

    Article  PubMed  Google Scholar 

  3. Plomin, R. & Kosslyn, S. M. Nat. Neurosci. 4, 1153–1155 (2001).

    Article  CAS  PubMed  Google Scholar 

  4. Posthuma, D., De Geus, E. J. C. & Boomsma, D. I. Behav. Genet. 31, 593–602 (2001).

    Article  CAS  PubMed  Google Scholar 

  5. Plomin, R., DeFries, J. C., Craig, I. W. & McGuffin, P. (eds). Behavioral Genetics in a Postgenomic Era (APA Books, Washington, DC, in press).

  6. Neale, M. C. & Cardon, L. R. Methodology for Genetic Studies of Twins and Families, NATO Asi Series, Ser. D, Behavioural and Social Sciences, Vol. 67 (Kluwer, Dordrecht, The Netherlands, 1992).

    Book  Google Scholar 

  7. Vernon, P. A., Wickett, J. C., Banzana, P. G. & Stelmack, R. M. in Handbook of Intelligence (ed. Sternberg, R. J.) 245–264 (Cambridge Univ. Press, 2000).

    Book  Google Scholar 

  8. Pennington, B. C. et al. J. Cogn. Neurosci. 12, 223–232 (2000).

    Article  CAS  PubMed  Google Scholar 

  9. Daneman, M. & Merikle, P. M. Psychon. Bull. Rev. 3, 422–433 (1996).

    Article  Google Scholar 

  10. Goldman-Rakic, P. S. Proc. Natl. Acad. Sci. USA 93, 13473–13480 (1996).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Neale, M. C. Mx: Statistical Modeling 3rd edn. (Medical College of Virginia, Richmond, VA, 1997).

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Author information

Authors and Affiliations

  1. Department of Biological Psychology, Vrije Universiteit Amsterdam, van der Boechorststraat 1, Amsterdam, 1081, BT, The Netherlands

    Daniëlle Posthuma, Eco J. C. De Geus & Dorret I. Boomsma

  2. Department of Psychiatry, University Medical Centre, Heidelberglaan 100, Utrecht, 3584, CX, The Netherlands

    Wim F. C. Baaré, Hilleke E. Hulshoff Pol & René S. Kahn

Authors
  1. Daniëlle Posthuma
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  2. Eco J. C. De Geus
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  3. Wim F. C. Baaré
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  4. Hilleke E. Hulshoff Pol
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  5. René S. Kahn
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  6. Dorret I. Boomsma
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Posthuma, D., De Geus, E., Baaré, W. et al. The association between brain volume and intelligence is of genetic origin. Nat Neurosci 5, 83–84 (2002). https://doi.org/10.1038/nn0202-83

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