A study in this issue finds that the chemoattractant cue, Sonic Hedgehog, can activate a repulsive response of commissural axonal pathfinding to Semaphorins, thereby acting as a 'switch' in axon guidance.
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Krull, C. Sonic Hedgehog gets another role. Nat Neurosci 13, 6–7 (2010). https://doi.org/10.1038/nn0110-6
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DOI: https://doi.org/10.1038/nn0110-6