Sonic Hedgehog gets another role

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A study in this issue finds that the chemoattractant cue, Sonic Hedgehog, can activate a repulsive response of commissural axonal pathfinding to Semaphorins, thereby acting as a 'switch' in axon guidance.

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Figure 1: Schematic diagram showing the Shh signaling pathway (adapted from ref. 3).

References

  1. 1

    Charron, F., Stein, E., Jeong, J., McMahon, A. & Tessier-Lavigne, M. Cell 113, 11–23 (2003).

  2. 2

    Chen, Z., Gore, B.B., Long, H., Ma, L., & Tessier-Lavigne, M. Neuron 58, 325–332 (2006).

  3. 3

    Parra, L. & Zou, Y. Nat. Neurosci. 13, 29–35 (2010).

  4. 4

    Yamada, T., Pfaff, S.L., Edlund, T., & Jessell, T.M. Cell 73, 673–686. (1993)

  5. 5

    Riddle, R.D., Johnson, R.L., Laufer, E., & Tabin, C. Cell 75, 1401–1416. (1993)

  6. 6

    Zou, Y., Stoeckli, E., Chen, H. & Tessier-Lavigne, M. Cell 102, 363–375 (2000).

  7. 7

    Terman, J.R. & Kolodkin, A.L. Science 303, 1204–1207 (2004).

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Correspondence to Catherine E Krull.

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Krull, C. Sonic Hedgehog gets another role. Nat Neurosci 13, 6–7 (2010) doi:10.1038/nn0110-6

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