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Dynamin-independent synaptic vesicle retrieval?

Nature Neuroscience volume 11, pages 6–8 (2008)Cite this article

A new study proposes that synaptic vesicle endocytosis at a large synaptic terminal is partly independent of dynamin and GTP hydrolysis, suggesting a new mechanism leading to vesicle fission and maintenance of neurotransmission.

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Figure 1: Xu et al.3 propose that the number of vesicles that can be retrieved via a dynamin- and GTP-dependent mechanism is fixed, and therefore only vesicles released in excess of this pool are recovered via an alternative mechanism.

Kim Caesar

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Authors and Affiliations

  1. Department of Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, 75390-9111, Texas, USA

    Helmut Krämer & Ege T Kavalali

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  1. Helmut Krämer
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  2. Ege T Kavalali
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Krämer, H., Kavalali, E. Dynamin-independent synaptic vesicle retrieval?. Nat Neurosci 11, 6–8 (2008). https://doi.org/10.1038/nn0108-6

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