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Monogamy: dopamine ties the knot

Nature Neuroscience volume 9, pages 7–8 (2006)Cite this article

Prairie voles form lasting pair bonds with their mating partners after a single experience of sexual activity, and this reward-related learning depends on dopamine. A new paper reports that two dopamine receptor subtypes contribute differently to the initial formation of pair bonds and to their maintenance by the promotion of selective aggression toward alternative mates.

Monogamy is rare among mammalian species, with only 3–5% forming lifelong pair bonds1. The prairie vole Microtus ochrogaster forms such enduring bonds after a single initial mating encounter, but why are these prairie-dwelling critters 'addicted to love' when their mountain- and meadow-dwelling cousins indulge in lifelong promiscuity? The answer may lie in the same neurobiological culprit already implicated in drug addiction, the neurotransmitter dopamine. In this issue, Aragona and colleagues2 report a role for particular dopamine receptor subtypes both in establishing pair bonds in sexually naive male prairie voles and also in maintaining the integrity of the bond after it has formed.

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Figure 1: Dopamine signaling in the formation and maintenance of pair bonds in male prairie voles.

Debbie Maizels

References

  1. Kleiman, D.G. Q. Rev. Biol. 52, 39–69 (1977).

    CAS  Article  Google Scholar 

  2. Aragona, B.J. et al. Nat. Neurosci. 9, 133–139 (2006).

    CAS  Article  Google Scholar 

  3. Insel, T.R. & Young, L.J. Nat. Rev. Neurosci. 2, 129–136 (2001).

    CAS  Article  Google Scholar 

  4. Insel, T.R. Physiol. Behav. 79, 351–357 (2003).

    CAS  Article  Google Scholar 

  5. Everitt, B.J. Neurosci. Biobehav. Rev. 14, 217–232 (1990).

    CAS  Article  Google Scholar 

  6. Pfaus, J.G. & Phillips, A.G. Behav. Neurosci. 105, 727–743 (1991).

    CAS  Article  Google Scholar 

  7. Aragona, B.J., Liu, Y., Curtis, J.T., Stephan, F.K. & Wang, Z. J. Neurosci. 23, 3483–3490 (2003).

    CAS  Article  Google Scholar 

  8. Reynolds, S.M. & Berridge, K.C. Eur. J. Neurosci. 17, 2187–2200 (2003).

    Article  Google Scholar 

  9. Steiner, H. & Gerfen, C.R. Exp. Brain Res. 123, 60–76 (1998).

    CAS  Article  Google Scholar 

  10. Young, L.J. & Wang, Z. Nat. Neurosci. 7, 1048–1054 (2004).

    CAS  Article  Google Scholar 

  11. Wang, Z. & Aragona, B.J. Physiol. Behav. 83, 319–328 (2004).

    CAS  Article  Google Scholar 

  12. Beninger, R.J. & Miller, R. Neurosci. Biobehav. Rev. 22, 335–345 (1998).

    CAS  Article  Google Scholar 

  13. Eyny, Y.S. & Horvitz, J.C. J. Neurosci. 23, 1584–1587 (2003).

    CAS  Article  Google Scholar 

  14. Kelley, A.E. Neuron 44, 161–179 (2004).

    CAS  Article  Google Scholar 

  15. Self, D.W., Barnhart, W.J., Lehman, D.A. & Nestler, E.J. Science 271, 1586–1589 (1996).

    CAS  Article  Google Scholar 

Download references

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  1. Department of Psychiatry, the Seay Center for Basic and Applied Research in Psychiatric Illness, University of Texas Southwestern Medical Center, Dallas, 75390-9070, Texas, USA

    Scott Edwards & David W Self

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  1. Scott Edwards
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  2. David W Self
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Edwards, S., Self, D. Monogamy: dopamine ties the knot. Nat Neurosci 9, 7–8 (2006). https://doi.org/10.1038/nn0106-7

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