Damaging secretions: chromogranins team up with mutant SOD1

A familial form of ALS is caused by mutations in the superoxide dismutase (SOD1) gene. A new paper shows that mutant SOD1 binds chromogranins in secretory vesicles and that its release promotes microgliosis and motor neuron death.

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Figure 1: Common signaling pathways of extracellular SOD1 and CgA.

Ann Thomson

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