A familial form of ALS is caused by mutations in the superoxide dismutase (SOD1) gene. A new paper shows that mutant SOD1 binds chromogranins in secretory vesicles and that its release promotes microgliosis and motor neuron death.
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Ann Thomson
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Sendtner, M. Damaging secretions: chromogranins team up with mutant SOD1. Nat Neurosci 9, 12–14 (2006). https://doi.org/10.1038/nn0106-12
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DOI: https://doi.org/10.1038/nn0106-12
