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VEGF: multitasking in ALS

Nature Neuroscience volume 8, pages 5–7 (2005)Cite this article

Amyotrophic lateral sclerosis is an incurable paralyzing disorder caused by the death of motor neurons in the spinal cord and brainstem. Patients typically die within three to five years. In this issue, Storkebaum and colleagues offer new evidence for VEGF action in motor neuron survival and new hope for direct delivery of VEGF into the nervous system as a therapy for ALS.

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Figure 1: The i.c.v. delivery of VEGF to motor neurons.

Debbie Maizels

Figure 2: Multitasking VEGF.

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Authors and Affiliations

  1. Ludwig Institute for Cancer Research and Departments of Medicine and Neuroscience, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093, California, USA

    Christine Vande Velde & Don W Cleveland

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  1. Christine Vande Velde
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  2. Don W Cleveland
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Velde, C., Cleveland, D. VEGF: multitasking in ALS. Nat Neurosci 8, 5–7 (2005). https://doi.org/10.1038/nn0105-5

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