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How does practice makes perfect?

Studies of nonhuman animals have taught us a great deal about how the brain changes during learning. An imaging study in this issue investigates how behavioral strategies interact with brain activation in humans during learning of a working memory task.

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Figure 1: Working memory task in which participants were shown a series of 4 × 4 matrices, each with a single cell marked in red.

Debbie Maizels


  1. Olesen, P.J., Westerberg, H. & Klingberg, T. Nat. Neurosci. 7, 75–79 (2004).

    Article  CAS  Google Scholar 

  2. Ashcraft, M.H. & Christy, K.S. J. Res. Math. Education 26, 396–421 (1995).

    Article  Google Scholar 

  3. Ungerleider, L.G., Doyon, J. & Karni, A. Neurobiol. Learn. Mem. 78, 553–564 (2002).

    Article  Google Scholar 

  4. Smith, E.E. & Jonides, J. Science 283, 1657–1661 (1999).

    Article  CAS  Google Scholar 

  5. Kastner, S. & Ungerleider, L.G. Annu. Rev. Neurosci. 23, 315–341 (2000).

    Article  CAS  Google Scholar 

  6. Barch, D.M. et al. Neuropsychologia 35, 1373–1380 (1997).

    Article  CAS  Google Scholar 

  7. Greenough, W.T., Withers, G.S. & Wallace, C.S. in The Biology of Memory, Symposia Medica Hoechst Vol. 23 (eds. Squire, L.R. & Lindenlaub, E.) 159–185 (F.K. Schattauder, New York, 1990).

    Google Scholar 

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Jonides, J. How does practice makes perfect?. Nat Neurosci 7, 10–11 (2004).

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