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Single-neuron responses to emotional visual stimuli recorded in human ventral prefrontal cortex

Abstract

Both lesion and functional imaging studies in humans1,2, as well as neurophysiological studies in nonhuman primates3, demonstrate the importance of the prefrontal cortex in representing the emotional value of sensory stimuli. Here we investigated single-neuron responses to emotional stimuli in an awake person with normal intellect. Recording from neurons within healthy tissue in ventral sites of the right prefrontal cortex, we found short-latency (120–160 ms) responses selective for aversive visual stimuli.

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Figure 1: Single-neuron responses to emotional stimuli.

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Acknowledgements

We thank I. Volkov, D. Tranel and N. Denburg for technical help. Supported by grants to R.A. from the Center for Consciousness Studies, the EJLB Foundation, and the Klingenstein Fund.

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Correspondence to Ralph Adolphs.

Supplementary information

Supplementary Figure 1

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Neuroanatomical location of recording sites shown in coronal MR scan. Four recording locations in the ventral prefrontal cortex are shown in red and were located at the tips of the electrodes. Each recording location indicated on the figure corresponds to a tetrode cluster of 4 adjacent contacts cut flush with the shaft's surface. Electrodes consisted of Pt-Ir wires (Ų 40µm, impedance 50-200 kΩ) within a teflon shaft (O.D. 1.25mm; Radionics, Burlington, Massachusetts)7. Intracranial EEG recordings demonstrated that interictal epileptiform activity and seizure onsets localized to the right posterior dorsal frontal lobe, distal to the recording location. All recordings presented in this report were obtained from brain tissue that showed no anatomical or electrophysiological abnormalities as detected with high-resolution MRI and EEG.

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Kawasaki, H., Adolphs, R., Kaufman, O. et al. Single-neuron responses to emotional visual stimuli recorded in human ventral prefrontal cortex. Nat Neurosci 4, 15–16 (2001). https://doi.org/10.1038/82850

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