Polymorphic computation in locus coeruleus networks

Physiological and optogenetic dissection of discrete locus coeruleus neuronal populations reveals a functional disassociation, with heterogeneous engagement of locus coeruleus neurons in either fear learning or extinction models.

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Figure 1: Polymorphic computation in locus coeruleus networks.

References

  1. 1

    Berridge, C.W. & Waterhouse, B.D. Brain Res. Brain Res. Rev. 42, 33–84 (2003).

  2. 2

    Uematsu, A. et al. Nat. Neurosci. 20, 1602–1611 (2017).

  3. 3

    Schwarz, L.A. & Luo, L. Curr. Biol. 25, R1051–R1056 (2015).

  4. 4

    Chandler, D.J., Gao, W.J. & Waterhouse, B.D. Proc. Natl. Acad. Sci. USA 111, 6816–6821 (2014).

  5. 5

    Schwarz, L.A. et al. Nature 524, 88–92 (2015).

  6. 6

    Kebschull, J.M. et al. Neuron 91, 975–987 (2016).

  7. 7

    Seo, D. & Monfils, M.H. Encyclopedia of the Sciences of Learning (2012).

  8. 8

    Giustino, T.F. & Maren, S. Front. Behav. Neurosci. 9, 298 (2015).

  9. 9

    Hentrich, D., Oruklu, E. & Saniie, J. Circuits and Systems 2, 358–364 (2011).

  10. 10

    McCall, J.G. et al. Neuron 87, 605–620 (2015).

  11. 11

    McCall, J.G. et al. eLife 6, e18247 (2017).

  12. 12

    Valentino, R.J. & Van Bockstaele, E. Eur. J. Pharmacol. 583, 194–203 (2008).

  13. 13

    Jennings, J.H. et al. Nature 496, 224–228 (2013).

  14. 14

    Challis, C. et al. J. Neurosci. 33, 13978–13988, 13988a (2013).

  15. 15

    Soiza-Reilly, M., Anderson, W.B., Vaughan, C.W. & Commons, K.G. Proc. Natl. Acad. Sci. USA 110, 15800–15805 (2013).

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Correspondence to Michael R Bruchas.

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The authors declare no competing financial interests.

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Seo, D., Bruchas, M. Polymorphic computation in locus coeruleus networks. Nat Neurosci 20, 1517–1519 (2017). https://doi.org/10.1038/nn.4663

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