Synuclein and dopamine: the Bonnie and Clyde of Parkinson's disease

Mouse models have generally failed to recapitulate the dopaminergic neurodegeneration seen in Parkinson's disease. Expressing mutant α-synuclein in a background of elevated dopamine generates mice with nigrostriatal degeneration.

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Figure 1: Schematic of a dopaminergic neuron with striatal synaptic terminals.

Change history

  • 20 December 2017

    In the version of this article initially published, the molecular mass of synuclein was given as 140 kDa instead of 14 kDa. The error has been corrected in the HTML and PDF versions of the article.

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Correspondence to Subhojit Roy.

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Roy, S. Synuclein and dopamine: the Bonnie and Clyde of Parkinson's disease. Nat Neurosci 20, 1514–1515 (2017). https://doi.org/10.1038/nn.4660

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