Steinman, L. Elaborate interactions between the immune and nervous systems. Nat. Immunol. 5, 575–581 (2004).
Irwin, M.R. & Cole, S.W. Reciprocal regulation of the neural and innate immune systems. Nat. Rev. Immunol. 11, 625–632 (2011).
Meisel, C., Schwab, J.M., Prass, K., Meisel, A. & Dirnagl, U. Central nervous system injury-induced immune deficiency syndrome. Nat. Rev. Neurosci. 6, 775–786 (2005).
Lucin, K.M., Sanders, V.M. & Popovich, P.G. Stress hormones collaborate to induce lymphocyte apoptosis after high level spinal cord injury. J. Neurochem. 110, 1409–1421 (2009).
Riegger, T. et al. Spinal cord injury-induced immune depression syndrome (SCI-IDS). Eur. J. Neurosci. 25, 1743–1747 (2007).
Oropallo, M.A. et al. Chronic spinal cord injury impairs primary antibody responses but spares existing humoral immunity in mice. J. Immunol. 188, 5257–5266 (2012).
Riegger, T. et al. Immune depression syndrome following human spinal cord injury (SCI): a pilot study. Neuroscience 158, 1194–1199 (2009).
Furlan, J.C., Krassioukov, A.V. & Fehlings, M.G. Hematologic abnormalities within the first week after acute isolated traumatic cervical spinal cord injury: a case-control cohort study. Spine 31, 2674–2683 (2006).
Brommer, B. et al. Spinal cord injury-induced immune deficiency syndrome enhances infection susceptibility dependent on lesion level. Brain 139, 692–707 (2016).
DeVivo, M.J., Kartus, P.L., Stover, S.L., Rutt, R.D. & Fine, P.R. Cause of death for patients with spinal cord injuries. Arch. Intern. Med. 149, 1761–1766 (1989).
Jackson, A.B. & Groomes, T.E. Incidence of respiratory complications following spinal cord injury. Arch. Phys. Med. Rehabil. 75, 270–275 (1994).
Failli, V. et al. Functional neurological recovery after spinal cord injury is impaired in patients with infections. Brain 135, 3238–3250 (2012).
Kopp, M.A. et al. Long-term functional outcome in patients with acquired infections after acute spinal cord injury. Neurology 88, 892–900 (2017).
Borovikova, L.V. et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 405, 458–462 (2000).
Martelli, D., Yao, S.T., McKinley, M.J. & McAllen, R.M. Reflex control of inflammation by sympathetic nerves, not the vagus. J. Physiol. (Lond.) 592, 1677–1686 (2014).
Zhang, Y. et al. Autonomic dysreflexia causes chronic immune suppression after spinal cord injury. J. Neurosci. 33, 12970–12981 (2013).
Ueno, M., Ueno-Nakamura, Y., Niehaus, J., Popovich, P.G. & Yoshida, Y. Silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury. Nat. Neurosci. 19, 784–787 (2016).
Meador, K.J. et al. Role of cerebral lateralization in control of immune processes in humans. Ann. Neurol. 55, 840–844 (2004).
Walter, U. et al. Insular stroke is associated with acute sympathetic hyperactivation and immunodepression. Eur. J. Neurol. 20, 153–159 (2013).
Williams, J.M. et al. Sympathetic innervation of murine thymus and spleen: evidence for a functional link between the nervous and immune systems. Brain Res. Bull. 6, 83–94 (1981).
Felten, D.L., Ackerman, K.D., Wiegand, S.J. & Felten, S.Y. Noradrenergic sympathetic innervation of the spleen: I. Nerve fibers associate with lymphocytes and macrophages in specific compartments of the splenic white pulp. J. Neurosci. Res. 18, 28–36, 118–121 (1987).
Previnaire, J.G., Soler, J.M., El Masri, W. & Denys, P. Assessment of the sympathetic level of lesion in patients with spinal cord injury. Spinal Cord 47, 122–127 (2009).
Wong, C.H., Jenne, C.N., Lee, W.Y., Léger, C. & Kubes, P. Functional innervation of hepatic iNKT cells is immunosuppressive following stroke. Science 334, 101–105 (2011).
Massberg, S. et al. Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. Cell 131, 994–1008 (2007).
Dembowsky, K., Czachurski, J., Amendt, K. & Seller, H. Tonic descending inhibition of the spinal somato-sympathetic reflex from the lower brain stem. J. Auton. Nerv. Syst. 2, 157–182 (1980).
Tibbs, P.A., Young, B., McAllister, R.G. Jr. & Todd, E.P. Studies of experimental cervical spinal cord transection. Part III: Effects of acute cervical spinal cord transection on cerebral blood flow. J. Neurosurg. 50, 633–638 (1979).
Rawe, S.E. & Perot, P.L. Jr. Pressor response resulting from experimental contusion injury to the spinal cord. J. Neurosurg. 50, 58–63 (1979).
Young, W., DeCrescito, V., Tomasula, J.J. & Ho, V. The role of the sympathetic nervous system in pressor responses induced by spinal injury. J. Neurosurg. 52, 473–481 (1980).
Edwards, A.V. & Jones, C.T. Autonomic control of adrenal function. J. Anat. 183, 291–307 (1993).
Parker, T.L., Kesse, W.K., Mohamed, A.A. & Afework, M. The innervation of the mammalian adrenal gland. J. Anat. 183, 265–276 (1993).
Holzwarth, M.A., Cunningham, L.A. & Kleitman, N. The role of adrenal nerves in the regulation of adrenocortical functions. Ann. NY Acad. Sci. 512, 449–464 (1987).
Dhabhar, F.S. & McEwen, B.S. Enhancing versus suppressive effects of stress hormones on skin immune function. Proc. Natl. Acad. Sci. USA 96, 1059–1064 (1999).
Andersson, U. & Tracey, K.J. Neural reflexes in inflammation and immunity. J. Exp. Med. 209, 1057–1068 (2012).
Dimitrov, S. et al. Cortisol and epinephrine control opposing circadian rhythms in T cell subsets. Blood 113, 5134–5143 (2009).
Scheiermann, C. et al. Adrenergic nerves govern circadian leukocyte recruitment to tissues. Immunity 37, 290–301 (2012).
Schedlowski, M. et al. Catecholamines modulate human NK cell circulation and function via spleen-independent beta 2-adrenergic mechanisms. J. Immunol. 156, 93–99 (1996).
Prass, K. et al. Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation. J. Exp. Med. 198, 725–736 (2003).
Lucin, K.M., Sanders, V.M., Jones, T.B., Malarkey, W.B. & Popovich, P.G. Impaired antibody synthesis after spinal cord injury is level dependent and is due to sympathetic nervous system dysregulation. Exp. Neurol. 207, 75–84 (2007).
Rouleau, P., Ung, R.V., Lapointe, N.P. & Guertin, P.A. Hormonal and immunological changes in mice after spinal cord injury. J. Neurotrauma 24, 367–378 (2007).
von Andrian, U.H. Intravital microscopy of the peripheral lymph node microcirculation in mice. Microcirculation 3, 287–300 (1996).
Kopp, M.A. et al. The SCIentinel study--prospective multicenter study to define the spinal cord injury-induced immune depression syndrome (SCI-IDS)--study protocol and interim feasibility data. BMC Neurol. 13, 168 (2013).
Fatima, G., Sharma, V.P. & Verma, N.S. Circadian variations in melatonin and cortisol in patients with cervical spinal cord injury. Spinal Cord 54, 364–367 (2016).