Supplementary Figure 9: Homing behavior of T cells after SCI. | Nature Neuroscience

Supplementary Figure 9: Homing behavior of T cells after SCI.

From: Spinal cord injury-induced immunodeficiency is mediated by a sympathetic-neuroendocrine adrenal reflex

Supplementary Figure 9

(a) In vivo imaging of the inguinal LN showed that rolling of T lymphocytes after SCI was not impaired. (b) In the shrunken brachial LN after SCI, the expression level of PNAd (MECA-79 antibody) appeared increased. (c) In contrast to spleen and LNs, homing to the bone marrow is only slightly changed with a subtle increase of CD4+ and CD8+ T cells. (d) BM mRNA expression of CXCL12 was increased. (e) BM of injured mice (3d post SCI) recruits ~5 times more mature B cells from the circulation 24 hours after injection. Homing to BM is completely abolished if B cells were pre-treated with pertussis toxin in vitro. Data are mean ± SEM, n=3-5 animals per group. * p<0.05; ** p<0.01; *** p<0.001, unpaired Student’s t test. Bar represents 1 mm in b.

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